Answer with Detailed explanation
Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is diagnosed in about 50% of patients diagnosed with SSc and is associated with a high mortality rate. As a substantial number of patients with SSc-ILD are asymptomatic, screening for SSc-ILD is of paramount importance. As the sensitivity and diagnostic accuracy of chest radiographs in SSc-ILD are very low, they are not indicated for ILD screening.
Lung function test is an important tool in the initial assessment and follow-up of patients with SSc-ILD. However, as the lung function test's false-negative rate is substantial, it cannot rule out SSc-ILD. Consequently, a current evidence-based European consensus statement suggests performing a screening HRCT in all patients with SSc-ILD at baseline.
By Prof Helmut Prosch, Associate Professor of Radiology, University of Vienna, Austria